Protein kinase C, membrane fusion and platelet granule secretion.

نویسندگان

  • J M Gerrard
  • A McNicol
  • S P Saxena
چکیده

7. Vahna-I’erttula, T. and Kasurinen, J. (1989) Int. J. Hiochem. 21,997-1007 8. Koldan, E. K. S. and Harrison, K. A. 1’ . (1900) Hiochem. Hiophys. Kes. Commun. 172.815 9. Harrison, K. A. I)., Koldan, E. K. S., Lander, L). J. and Irvine, K. F. (1990) Cell. Signalling 2.277-284 10. Hinkovska-Galchev, V. and Srivastava, P. N. (1992) Mol. Reprod. Dev. 33,28 1-286 11. Domino, S. E., Bocckino, S. B. and Garbers, D. L. (1989) J. Biol. Chem. 264,9412-9419 12. Rider, I,. G., Dougherty, R. W. and Niedel, J. E. (1988) J. Immunol. 140,200-207 13. Selivonchick, L). I’.. Schmid, 1’. c. , Natardjan, V. and Schmid, H. H. 0. (1980) Hiochim. Hiophys. Acta 618, 242-254 14. Aveldaiio, M. I.. Kotstein, N. 1’. and Vermouth. N. T. (1992) Hiochem. J. 283,235-241 15. tlokin. I,. E. (1985) Annu. Rev. Hiochem. 54,

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A role for protein kinase C in the membrane fusion necessary for platelet granule secretion.

The addition of 1-oleoyl-2-acetylglycerol (OAG), or phorbol-12-myristate-13-acetate (PMA) to platelets induced the phosphorylation of a 47,000 dalton protein (47 Kd), fusion of granule membranes with membranes of the surface connected canalicular system, the formation of large vesicles and the secretion of serotonin. 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine (H7), and sphingosine, inhibito...

متن کامل

A critical role for N-ethylmaleimide-sensitive fusion protein (NSF) in platelet granule secretion.

The molecular mechanisms that regulate membrane targeting/fusion during platelet granule secretion are not yet understood. N-ethylmaleimide-sensitive fusion protein (NSF), soluble NSF attachment proteins (SNAPs), and SNAREs (SNAP receptors) are elements of a conserved molecular machinery for membrane targeting/fusion that have been detected in platelets. We examined whether NSF, an ATPase that ...

متن کامل

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY A Critical Role for N-ethylmaleimide–Sensitive Fusion Protein (NSF) in Platelet Granule Secretion

The molecular mechanisms that regulate membrane targeting/fusion during platelet granule secretion are not yet understood. N-ethylmaleimide-sensitive fusion protein (NSF), soluble NSF attachment proteins (SNAPs), and SNAREs (SNAP receptors) are elements of a conserved molecular machinery for membrane targeting/fusion that have been detected in platelets. We examined whether NSF, an ATPase that ...

متن کامل

Molecular basis of platelet granule secretion.

The energy-dependent release of granule contents from activated platelets is a well-established component of normal hemostasis and thrombosis. A role for membrane fusion in this process has been presumed for decades, but only recently have the mechanisms of platelet membrane fusion been investigated at the molecular level. Such studies have demonstrated that platelet membrane fusion is controll...

متن کامل

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY The actin cytoskeleton differentially regulates platelet -granule and dense-granule secretion

Stimulation of platelets with strong agonists results in centralization of cytoplasmic organelles and secretion of granules. These observations have led to the supposition that cytoskeletal contraction facilitates granule release by promoting the interaction of granules with one another and with membranes of the open canalicular system. Yet, the influence of the actin cytoskeleton in controllin...

متن کامل

ATVB In Focus Platelet Activation and the Formation of the Platelet Plug

The energy-dependent release of granule contents from activated platelets is a well-established component of normal hemostasis and thrombosis. A role for membrane fusion in this process has been presumed for decades, but only recently have the mechanisms of platelet membrane fusion been investigated at the molecular level. Such studies have demonstrated that platelet membrane fusion is controll...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Biochemical Society transactions

دوره 21 2  شماره 

صفحات  -

تاریخ انتشار 1993